I purchased my 06 TSX new with 7 miles on the odo and now have +130,000 miles 10 years later. It has been routine maint, tires, battery, alternator, and a few worn suspension parts. Paint still looks good for living its life in the southwestern sun. My TSX looks almost as good inside and out as the day I purchased her and everything works perfectly. I see less TSXs on the road compared to RDXs around the same model year. I think it is because it is SUV/CUV country out here compared to sedans/coupes. The TSXs I do see are starting too look like 2nd/3rd hand me down vehicles you give to your high school kid to play bumper cars with (sun damage paint, dented bumpers, cracks in the windshields, crappy tint jobs, etc...). I handed down my TSX to my son 2 years ago when he turned 16. He really love this car and is planning to keep it after he graduates college. I don't see why it wouldn't last another 4-5 more years.
The only vehicle I can think of as an replacement is the 2.4L TLX. I'm waiting until 17/18 model year to see if the fix the 8AT issues, offer an Adv version of the 2.4L (cooled seats are nice in the southwest), and/or offer the Acura Watch safety suite to 2.4L tech version.
Son - 06 TSX 5AT w/ Navi, Carbon Gray w/ Quartz (handed down for 16th B-day Mar/14)
His - 08 RDX Tech, Moroccan Red Pearl w/ Taupe (finally replaced Takata airbag on 6/16/16 after 86 days with rental)
Her - 11 MDX Adv/Ent, Palladium Metallic w/ Ebony