I just posted this topic on azine because my gf's 07 RDX experienced the same issue. I wasn't there so I was just posting based on what she said. She was going 60+mph on the highway after it had been completely cleared, prob 7/10 on clean scale, and she noticed an extremely violent shaking of the car and the steering wheel. We in Maryland just got hammered by snow too.
I thought it could've been a few issues.
1) Driving in the wrong gear by accident
2) E-Brake on
3) Power Steering
4) Balance and alignment seriously messed up
5) Snow packed in wheel wells
Turned out to be #5, and her local Acura dealership also suggested that immediately. I guess they've been taking loads of calls from Acura owners with similar issues.
I dont think this will hurt your alignment. Sometimes that snow just gets packed real solid in there. Just take it slow and keep clearing the wells. If you notice your car is pulling to the side in normal road conditions and without snow in the wells, then you might want to get it checked out.